Department of Biochemistry and Molecular Biophysics
Alexander Sobolevsky (Sasha) earned his Ph.D. in biophysics in 1999 from the Moscow Institute of Physics and Technology, studying ion channel block of NMDA-subtype ionotropic glutamate receptors (iGluRs) under guidance of Prof. Boris Khodorov. He held his first postdoctoral position in 2000, studying functional architecture of iGluRs by cysteine scanning mutagenesis with Dr. Lonnie Wollmuth at the State University of
New York, Stony Brook. He continued his studies of structure and function of iGluRs with Dr. Eric Gouaux, first at Columbia University and then at the Oregon Health and Science University, where he solved the first crystal structure of an intact iGluR. Sasha joined Columbia University’s faculty in 2010 as an Assistant Professor of biochemistry and molecular biophysics, focusing on structure and function of ion channels, iGluRs and transient receptor potential (TRP) channels in particular. In 2016, his lab solved the first crystal structure of an intact TRP channel (TRPV6). In 2017, he was promoted to an Associate Professor. Sasha is a recipient of the Klingenstein Award in the Neurosciences, Schaefer Research Scholar Award, Pew Scholar Award, Irma T. Hirschl Career Scientist Award and Amgen Young Investigator Award.