Professor, Department of Molecular Biosciences
Alfonso Mondragón received his Ph.D. from Cambridge University in 1985 working with Sir Aaron Klug on the structure of Tobacco Mosaic Virus. From 1985 to 1989 he conducted post-doctoral studies in the laboratory of Stephen C. Harrison at Harvard University working on the structure of bacterial repressors. He joined Northwestern University in 1989 and established his own laboratory. His research is concerned with the structure and function of biological macromolecules, in particular nucleic acids and proteins that modify and interact with them. He studies the structure and function of topoisomerases by a variety of biophysical techniques to elucidate their mechanism of action. He is also interested in the structure and function of large non-coding RNA molecules, including RNase P, a large ribozyme responsible for tRNA processing, and T-box riboswitches.