Member and Laboratory Head, Structural Biology Program
Memorial Sloan Kettering Cancer Center
Stephen B. Long, Ph.D., is a Member and Laboratory Head in the Structural Biology Program of Memorial Sloan Kettering Cancer Center in New York City. He serves as a Professor in the Gerstner Sloan Kettering Graduate School of Biomedical Sciences and in the Weill Cornell Graduate School of Medical Sciences. Dr. Long received his B.A. in Physics from Amherst College, his Ph.D. in Biochemistry from Duke University, and Postdoctoral training at the Rockefeller University. Dr. Long’s research aims to understand the atomic structures and molecular mechanisms of ion channels and membrane-embedded enzymes.
The scientific milestones of his laboratory include the structures of four eukaryotic ion channels and the structure of a membrane enzyme that modifies Ras, mutations of which are one of the major drivers of cancer. His research provided the first atomic pictures of these proteins, which underlie processes that include neuronal signals, immune responses, energy production, and cellular proliferation. Of particular note, the discoveries include the first visualization of any calcium channel. His laboratory combines structural information with techniques that address function to understand the detailed workings of these complex molecular machines. Dr. Long is longtime member of Central Presbyterian Church in New York City, where he has served as an Elder. He lives in New York City with his three children and wife, Meredith B. Long, PhD, who is a middle school science teacher.